8/3/2023 0 Comments Cardionavigator software![]() Serum values of sST2 were higher in SSc patients with DD than in patients without DD. A linear positive correlation between modified Rodnan skin score and I元3 was observed. Serum levels of IL-33 and sST2 were significantly higher in SSc patients than HC. Clinical assessment, echocardiography and heart rate variability (HRV) analysis were performed in SSc patients. Serum levels of I元3 and sST2 were assessed in 50 SSc patients and 14 healthy controls (HC). In systemic sclerosis (SSc), IL-33 and sST2 are involved in cardiac manifestations such as diastolic dysfunction (DD), autonomic dysfunction (AD) and right ventricular–pulmonary arterial coupling assessed by tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP). ![]() Interleukin (IL)-33 is part of the IL-1 family of cytokines and soluble suppression of tumorigenicity 2 (sST2) is part of the family of IL-1 receptors.
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